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Spirulina contains an unusually high amount of protein, between 55% and 77% by dry weight, depending upon the source. It is a complete protein,[citation needed] containing all essential amino acids, though with reduced amounts of methionine, cysteine, and lysine when compared to the proteins of meat, eggs, and milk. It is, however, superior to typical plant protein, such as that from legumes.
Essential fatty acids

Spirulina tabletsSpirulina is rich in gamma-linolenic acid (GLA), and also provides alpha-linolenic acid (ALA), linoleic acid (LA), stearidonic acid (SDA),eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA).

Vitamins
Spirulina contains vitamin B1 (thiamine), B2 (riboflavin), B3 (nicotinamide), B6 (pyridoxine), B9 (folic acid), vitamin C, vitamin D, and vitamin E.
B12
The bioavailability of vitamin B12 in Spirulina is in dispute. Several biological assays have been used to test for the presence of vitamin B12. The most popular is the US Pharmacopeia method using the Lactobacillus leichmannii assay. Studies using this method have shown Spirulina to be a minimal source of bioavailable vitamin B12. However, this assay does not differentiate between true B12 (cobalamin) and similar compounds (corrinoids) that cannot be used in human metabolism. Cyanotech, a grower of spirulina, claims to have done a more recent assay, which has shown Spirulina to be a significant source of cobalamin. However, the assay is not published for scientific review and so the validity of this assay is in doubt. The American Dietetic Association and Dietitians of Canada in their position paper on vegetarian diets state that spirulina can not be counted on as a reliable source of active vitamin B12.

Tests done on Australian-grown spirulina by the Australian Government Analytical Laboratory (AGAL) show Vitamin B12 (cobalamin) levels of 659.1 ug / per100g A one gram tablet could provide more than three times the recommended daily intake of B12.
Minerals
Spirulina is a rich source of potassium, and also contains calcium, chromium, copper, iron, magnesium, manganese, phosphorus, selenium, sodium, and zinc.
Photosynthetic pigments
Spirulina contains many pigments including chlorophyll-a, xanthophyll, beta-carotene, echinenone, myxoxanthophyll, zeaxanthin, canthaxanthin, diatoxanthin, 3′-hydroxyechinenone, beta-cryptoxanthin, oscillaxanthin, plus the phycobiliproteins c-phycocyanin and allophycocyanin.
Benefits of Spirulina
Spirulina is effective for the clinical improvement of melanosis and keratosis due to chronic arsenic poisoning; improves weight-gain and corrects anemia in both HIV-infected and HIV-negative undernourished children; and protects against hay fever.

A 2007 study found that 36 volunteers taking 4.5 grams of spirulina per day, over a six week period, exhibited significant changes in cholesterol and blood pressure: (1) lowered total cholesterol; (2) increased HDL cholesterol; (3) lowered triglycerides; and (4) lowered systolic and diastolic blood pressure. Spirulina has also been found to be clinically effective against allergic rhinitis, a condition that can lead to chronic sinusitis.

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